Materials Science of Drugs Kierunek studiów: Biofizyka
Kod programu: W4-S2BFA21.2022

Nazwa modułu: Materials Science of Drugs
Kod modułu: W4-2BF-MB-21-13
Kod programu: W4-S2BFA21.2022
Semestr:
  • semestr letni 2024/2025
  • semestr letni 2023/2024
  • semestr letni 2022/2023
Język wykładowy: angielski
Forma zaliczenia: zaliczenie
Punkty ECTS: 4
Opis:
The purpose of this unit is to provide an overview of the thermodynamics of phase equilibrium and phase transitions, with application to the polymorphism of drugs, and to introduce binary phase diagrams and the non-equilibrium glass state, with applications in the field of amorphous drugs. Course syllabus: (1) Basic concepts of crystallography: translational order, unit cell, Bravais lattices. Point groups, space groups, crystal systems. Crystallographic planes, reciprocal lattice, Miller indices. From crystal system to molecular structure and geometry: crystals with a base and molecular crystals. Calculation and modeling of diffraction patterns from atomic and structure scattering factors. Solid-state polymorphism of drugs and other organic molecules. (2) Phase Equilibrium and phase transitions (Thermodynamic Potentials for hydrostatic pvT systems; Maxwell relations; TdS equations; General conditions for equilibrium; Fluctuations; Le Châtelier principle) (3) Phase transitions and topological pressure-temperature phase diagram (Equilibrium conditions for hydrostatic pvT systems; First-order phase transitions: Clausius-Clapeyron equation. Stability and metastability domains; High-order phase transitions. Group-subgroup phase transitions. Second-harmonic generation; Critical and triple points; Topological P-T phase diagram. (4) Landau's theory for phase transitions. Ferroelastic phase transitions. Long-range anisotropic interactions. Self-accommodation. Structural phase transitions. Mechanistic and kinetic classification of phase transitions. (5) Phases out of equilibrium (Glass state and glass transition; dynamics and structural relationships in the glass state; pressure dependence of the glass transition temperature; non-equilibrium phases and mesophases of drugs) (6) Binary systems (thermodynamics of mixing, thermodynamic potential; types of binary phase diagrams: eutectic, metatectic, and peritectic; solubility and miscibility; metastable and unstable states; nucleation vs spinoidal decomposition. The course will include laboratory sessions.
Wymagania wstępne:
(brak informacji)
Literatura podstawowa:
(brak informacji)
Efekt modułowy Kody efektów kierunkowych do których odnosi się efekt modułowy [stopień realizacji: skala 1-5]
students will be able to discuss the equilibrium conditions for a phase or phase coexistence, draw multiphase and/or binary phase diagrams, and distinguish between different equilibrium, metastable, and unstable states, and their relevance for drug formulations [MB_13_1]
 KBF_W02 [4/5] KBF_U01 [4/5] KBF_U02 [4/5] KBF_U11 [3/5] KBF_K06 [3/5]
Typ Opis Kody efektów modułowych do których odnosi się sposób weryfikacji
zaliczenie [MB_13_w_1]
the basis for obtaining credit will be the grades from homework and laboratory reports
 MB_13_1
Rodzaj prowadzonych zajęć Praca własna studenta Sposoby weryfikacji
Typ Opis (z uwzględnieniem metod dydaktycznych) Liczba godzin Opis Liczba godzin
wykład [MB_13_fs_1]
Detailed discussion by the lecturer of the issues listed in the table "module description" using the table and/or multimedia presentations
 30
Supplementary reading, working with the textbook, doing homework
 45 zaliczenie [MB_13_w_1]
laboratorium [MB_13_fs_2]
Performance of exercises on the subject consistent with the issues listed in the table "module description"
 6
Acquiring knowledge in the scope of the exercise, preparation of the final report on a given exercise
 19 zaliczenie [MB_13_w_1]
Załączniki
Opis modułu (PDF)
Informacje o sylabusach mogą ulec zmianie w trakcie trwania studiów.
Sylabusy (USOSweb)
Semestr Moduł Język wykładowy
(brak danych)