Materials Science of Drugs Field of study: Biophysics
Programme code: W4-S2BFA21.2022

Module name: Materials Science of Drugs
Module code: W4-2BF-MB-21-13
Programme code: W4-S2BFA21.2022
Semester:
  • summer semester 2024/2025
  • summer semester 2023/2024
  • summer semester 2022/2023
Language of instruction: English
Form of verification: course work
ECTS credits: 4
Description:
The purpose of this unit is to provide an overview of the thermodynamics of phase equilibrium and phase transitions, with application to the polymorphism of drugs, and to introduce binary phase diagrams and the non-equilibrium glass state, with applications in the field of amorphous drugs. Course syllabus: (1) Basic concepts of crystallography: translational order, unit cell, Bravais lattices. Point groups, space groups, crystal systems. Crystallographic planes, reciprocal lattice, Miller indices. From crystal system to molecular structure and geometry: crystals with a base and molecular crystals. Calculation and modeling of diffraction patterns from atomic and structure scattering factors. Solid-state polymorphism of drugs and other organic molecules. (2) Phase Equilibrium and phase transitions (Thermodynamic Potentials for hydrostatic pvT systems; Maxwell relations; TdS equations; General conditions for equilibrium; Fluctuations; Le Châtelier principle) (3) Phase transitions and topological pressure-temperature phase diagram (Equilibrium conditions for hydrostatic pvT systems; First-order phase transitions: Clausius-Clapeyron equation. Stability and metastability domains; High-order phase transitions. Group-subgroup phase transitions. Second-harmonic generation; Critical and triple points; Topological P-T phase diagram. (4) Landau's theory for phase transitions. Ferroelastic phase transitions. Long-range anisotropic interactions. Self-accommodation. Structural phase transitions. Mechanistic and kinetic classification of phase transitions. (5) Phases out of equilibrium (Glass state and glass transition; dynamics and structural relationships in the glass state; pressure dependence of the glass transition temperature; non-equilibrium phases and mesophases of drugs) (6) Binary systems (thermodynamics of mixing, thermodynamic potential; types of binary phase diagrams: eutectic, metatectic, and peritectic; solubility and miscibility; metastable and unstable states; nucleation vs spinoidal decomposition. The course will include laboratory sessions.
Prerequisites:
(no information given)
Key reading:
(no information given)
Learning outcome of the module Codes of the learning outcomes of the programme to which the learning outcome of the module is related [level of competence: scale 1-5]
students will be able to discuss the equilibrium conditions for a phase or phase coexistence, draw multiphase and/or binary phase diagrams, and distinguish between different equilibrium, metastable, and unstable states, and their relevance for drug formulations [MB_13_1]
 KBF_W02 [4/5] KBF_U01 [4/5] KBF_U02 [4/5] KBF_U11 [3/5] KBF_K06 [3/5]
Type Description Codes of the learning outcomes of the module to which assessment is related
credit [MB_13_w_1]
the basis for obtaining credit will be the grades from homework and laboratory reports
 MB_13_1
Form of teaching Student's own work Assessment of the learning outcomes
Type Description (including teaching methods) Number of hours Description Number of hours
lecture [MB_13_fs_1]
Detailed discussion by the lecturer of the issues listed in the table "module description" using the table and/or multimedia presentations
 30
Supplementary reading, working with the textbook, doing homework
 45 credit [MB_13_w_1]
laboratory classes [MB_13_fs_2]
Performance of exercises on the subject consistent with the issues listed in the table "module description"
 6
Acquiring knowledge in the scope of the exercise, preparation of the final report on a given exercise
 19 credit [MB_13_w_1]
Attachments
Module description (PDF)
Information concerning module syllabuses might be changed during studies.
Syllabuses (USOSweb)
Semester Module Language of instruction
(no information given)