Pharmacology and Pharmacognosy Field of study: Biophysics
Programme code: W4-S2BFA21.2022

Module name: Pharmacology and Pharmacognosy
Module code: W4-2BF-MB-21-27
Programme code: W4-S2BFA21.2022
Semester:
  • winter semester 2025/2026
  • winter semester 2024/2025
  • winter semester 2023/2024
Language of instruction: English
Form of verification: exam
ECTS credits: 5
Description:
The content of the lecture includes: 1. Subject and basic concepts of pharmacology, pharmacy and pharmacognosy. 2. Drug nomenclature. Drug forms. 3. Drug properties and types of actions in the body. Side effects. Drug toxicity. 4. Factors affecting drug performance. Drug absorption. Fundamentals of drug action mechanisms. Non-specific drugs. 5. Drug distribution, redistribution and biotransformation. Drug excretion. Drug transport. 6. Chemical stability of the drug. Structural determinants of chemical stability. Structural factors affecting durability. 7. Drug metabolite. First phase processes 8. Pharmacokinetics. The concept of a model compartment. 9. Cell structure and drugs. Drugs in the organism. Basic information about the cell and cellular mechanisms of drug action. 10. Hydrophobicity vs hydrophilicity. Ionization of the drug. Lipinski rule and pharmacokinetics. 11. ADMET and pharmacokinetics. Pharmacokinetics and drug design. 12. Solubility and transport through membranes. The effect of acyl and alkyl substituents and their substitution on drug polarity. 13. Introduction of genes to cells. Antisense therapy. Prodrugs generated by genetic engineering. 14. Pharmacogenetics (pharmacogenomics). Genomics technology in the search for drugs. Laboratory - selected issues: 1) Oxidation reactions. Aromatic hydroxylation. Epoxidation of alkenes. 2) Oxidation of aliphatic and alicyclic carbon atoms. Oxidation of moieties containing a carbon-nitrogen connection. 3) Oxidation of the carbon-oxygen bond. 4) Reduction reactions. Reduction of the carbonyl group. Reduction of the nitro group. Azo group reduction. Reduction of tertiary amine oxides. Reductive halogen removal. 5) Hydrolysis reactions. 6) Second phase processes - coupling reactions. Coupling with glucuronic acid. Coupling with sulfuric acid. Coupling with amino acids. Coupling with glutathione. Coupling with water. Coupling with acetic acid.
Prerequisites:
(no information given)
Key reading:
(no information given)
Learning outcome of the module Codes of the learning outcomes of the programme to which the learning outcome of the module is related [level of competence: scale 1-5]
Student knows the basic concepts of pharmacy and pharmacognosy [MB_27_1]
 KBF_W01 [4/5] KBF_W02 [4/5] KBF_W09 [4/5] KBF_U03 [4/5] KBF_K04 [4/5]
Student learned the properties of active substances, their action in the body, side effects [MB_27_2]
 KBF_W01 [3/5] KBF_W02 [3/5] KBF_W09 [3/5] KBF_U03 [3/5] KBF_K06 [3/5]
Understands the basics of drug action mechanisms [MB_27_3]
 KBF_W01 [3/5] KBF_W02 [3/5] KBF_W09 [3/5] KBF_U03 [3/5] KBF_K02 [3/5]
Student learned about the chemical conditions of the use of active substances and the biochemical reactions at the cell level [MB_27_4]
 KBF_W01 [3/5] KBF_W02 [3/5] KBF_W09 [3/5] KBF_U03 [3/5] KBF_K02 [3/5]
Student knows and understands the use of prodrugs generated by genetic engineering [MB_27_5]
 KBF_W01 [3/5] KBF_W02 [3/5] KBF_W09 [3/5] KBF_U03 [3/5] KBF_K05 [3/5]
Student knows how to use genomics technology in search of drugs [MB_27_6]
 KBF_W01 [3/5] KBF_W02 [3/5] KBF_W09 [3/5] KBF_U03 [3/5] KBF_K05 [3/5]
Student has the basic ability to work in a synthesis laboratory [MB_27_7]
 KBF_W01 [3/5] KBF_W02 [3/5] KBF_W09 [3/5] KBF_U03 [3/5] KBF_K03 [3/5]
Type Description Codes of the learning outcomes of the module to which assessment is related
credit [MB_27_w_1]
Positive assessment of the test allowing to perform a given exercise
 MB_27_1 MB_27_2 MB_27_3 MB_27_4 MB_27_5 MB_27_6 MB_27_7
written test/ oral examination [MB_27_w_2]
Written / oral exam from the material presented during the lecture
 MB_27_1 MB_27_2 MB_27_3 MB_27_4 MB_27_5 MB_27_6 MB_27_7
Form of teaching Student's own work Assessment of the learning outcomes
Type Description (including teaching methods) Number of hours Description Number of hours
laboratory classes [MB_27_fs_1]
Self-performance of exercises, ability to prepare reports, ability to describe the results obtained
 30
Preparation of a report on the given exercise
 30 credit [MB_27_w_1]
lecture [MB_27_fs_2]
The lecture is conducted with the use of multimedia resources, with the use of own presentations and materials from the e-learning platform
 30
Supplementing the knowledge obtained during the lectures with additional literature. Using lectures posted on the e-learning platform
 30 written test/ oral examination [MB_27_w_2]
Attachments
Module description (PDF)
Information concerning module syllabuses might be changed during studies.
Syllabuses (USOSweb)
Semester Module Language of instruction
(no information given)